Fr. Krick proceeded to Nagaon and from there to Dibrugarh with the intention of going to Tibet. In 1854, Fr. Krick and Fr. Bourry were killed in the Mishmi Hills while trying to enter Tibet.

Fr. Jacopo Broy of the Institute of the Foreign Missions of Milan took up residence in Guwahati and built a brick church here in 1883. From this central place he looked after the entire 'Assam Missions'. Soon we find him in Nagaon where he later built a small church.

In 1889 the prefecture Apostolic of Assam was created with headquarters at Shillong and was entrusted to the German Salvatorian Fathers. In February 1890 the German Salvatorian Missionaries Frs. Gallus Schrole and Rudolph Fontaine reached Guwahati. They were the two great missionaries of the Assam Valley. By this time many Tribal Catholics from Chota Nagpur had come to work in the Tea Gardens of Assam. With the outbreak of World War 1, the German Salvatorian Fathers were forced to return to their country. The Jesuits of Calcutta looked after the Assam mission till the Holy See entrusted it to the Salesians of Don Bosco in 1921.

In 1922, the Salesians of Don Bosco arrived in Northeast India under the leadership of Fr. Louis Mathias. In 1923 Fr. Leo Piasecki, known as the Lion of Brahmaputra Valley, took charge of the Mission in Guwahati which at that time covered the entire Brahmaputra Valley, Nagaland and Manipur. Assam Mission hen consisted of the whole of North East. Shillong was the capital of undivided Assam. In 1934 when Shillong was made a Diocese Msgr Louis Mathias SDB was appointed as its first Bishop. Msgr Stephen Ferrando succeeded him in 1935.

From Guwahati missionary work reached to Dibrugarh, Tezpur, Garo Hills and Bhutan. Some of the first Catholics of Manipur and Nagaland had studied at Guwahati.

The Diocese of Guwahati was erected by Pope John Paul II on August 1992 with Bishop Thomas Menamparampil as its first Archbishop. It was carved out of the Dioceses of Shillong, Tura and Tezpur, the last contributing the largest portion.